Journal: Neurotherapeutics

Article Title: Spreading depolarization suppression from inter-astrocytic gap junction blockade assessed with multimodal imaging and a novel wavefront detection scheme

doi: 10.1016/j.neurot.2023.10.008

Figure Lengend Snippet: Multi-modality rodent optical imaging system. a) System diagram showing separate light paths and synchronization with LFP recording. Legend: CMOS and EM-CCD: cameras for NIR imaging and autofluorescence (AF), respectively, E-Src & E-Swt: current source and switch, respectively, Int: interface adaptor, Ex/Em: AF band-pass filters, LP: long-pass filter and dichroic mirror, Int: pin adapter interface, and VCSEL for NIR illumination module. b) Electrode and illumination source arrangement on cortex. c) The FOV for LSCI, IOSI and AF at 4× ​magnification.

Article Snippet: A multi-wavelength (680 ​nm, 795 ​nm, and 850 ​nm) vertical-cavity surface-emitting laser (VCSEL) package (Vixar, Inc.) was used to provide oblique NIR illumination.

Techniques: Optical Imaging, Imaging

Journal: Neurotherapeutics

Article Title: Spreading depolarization suppression from inter-astrocytic gap junction blockade assessed with multimodal imaging and a novel wavefront detection scheme

doi: 10.1016/j.neurot.2023.10.008

Figure Lengend Snippet: Multi-modality rodent optical imaging system, illumination scheme. a) The AF and multi-modal NIR imaging channels compared to hemoglobin molecular extinction coefficient (ϵ). Fluorescent cube ex/em band-pass indicated by blue/green regions, respectively. The dotted red lines show the VCSEL wavelengths. b) ​Modality synchronization and current switching sequence for VCSELs.

Article Snippet: A multi-wavelength (680 ​nm, 795 ​nm, and 850 ​nm) vertical-cavity surface-emitting laser (VCSEL) package (Vixar, Inc.) was used to provide oblique NIR illumination.

Techniques: Optical Imaging, Imaging, Sequencing